Quinolin-2-yl-2-boronic acid - Names and Identifiers
Quinolin-2-yl-2-boronic acid - Physico-chemical Properties
Molecular Formula | C9H8BNO2
|
Molar Mass | 172.98 |
Density | 1.28±0.1 g/cm3(Predicted) |
Melting Point | >300 C |
Boling Point | 400.3±37.0 °C(Predicted) |
Flash Point | 195.871°C |
Vapor Presure | 0mmHg at 25°C |
pKa | 4.11±0.30(Predicted) |
Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
Refractive Index | 1.645 |
Quinolin-2-yl-2-boronic acid - Risk and Safety
Hazard Symbols | Xi - Irritant
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Risk Codes | 36/38 - Irritating to eyes and skin.
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Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39 - Wear suitable gloves and eye/face protection
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Quinolin-2-yl-2-boronic acid - Introduction
2-quinolinyl-boronic acid is an organic compound with the chemical formula C9H8BNO2. The following is a description of its nature, use, preparation and safety information:
Nature:
- 2-quinolinyl-boronic acid is a white solid, soluble in some organic solvents such as dichloromethane and chloroform.
-It is electrophilic and can be used as an important reagent in organic synthesis.
-It can react with alkenes, alkynes, halogenated hydrocarbons, etc. to form C- B bonds.
- 2-quinolinyl-boronic acid has good stability and can be stored under dry conditions.
Use:
- 2-quinolinyl-boronic acid is widely used in organic synthesis, especially in metal-catalyzed reactions.
-It can be used as a ligand to form a complex with transition metals, and participate in redox, palladium-catalyzed reactions.
- 2-quinolinyl-boronic acid also has certain applications in drug research and pesticide synthesis.
Preparation Method:
- 2-quinolinyl-boronic acid can be prepared by the reaction of benzyl compound and boric acid. The reaction is generally carried out under inert gas.
-Boronic acid can be selectively added to benzyl to form 2-quinolinyl-boronic acid.
Safety Information:
- 2-quinolinyl-boronic acid is a chemical reagent that requires compliance with laboratory safety practices.
-Its dust may cause irritation to the skin, eyes and respiratory system.
-During use, avoid inhalation or contact with skin and eyes.
-When storing, keep it in a dry, dark and well-ventilated place, and avoid contact with oxidants and high temperatures.
Last Update:2024-04-09 02:00:48